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. 2014 Mar 1;12(2):110–119. doi: 10.1089/adt.2013.552

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© Kuryshev et al. 2014; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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Fig. 4. — Use-dependent block of Ca_v2.2 by mibefradil. (A) Time course of Ca_v2.2 inhibition with mibefradil during repetitive stimulation. The currents were elicited with test pulses to +20 mV from a holding potential −90 mV with 0.1 Hz frequency (30 stimulations in total); data were run down, corrected using time-matching vehicle control and presented as mean±SD (n=4 per concentration). (B) Dose–response curves for the first (TP1) and last (TP30) stimulation test pulses (mean±SD). Mibefradil tonic block IC₅₀=32.7 μM, use-dependent block IC₅₀=4.8 μM.