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. 2015 Nov 10;2016:9392404. doi: 10.1155/2016/9392404

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Copyright © 2016 Zhi-Gang Jiang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of PAN-811·Cl·H₂O on anticancer drug-induced cytotoxicities to human cancer cell H460. (a) Phase contrast photographs for the H460 cells that received 25 μM 5-FU, 10 μM PAN-811, or both for 3 days (bar = 50 μm). (b)–(d) MTS analysis for the H460 cells that received 10 μM PAN-811·Cl·H₂O, one of 100 μM MTX, 25 μM 5-FU, and 3.5 μM CDDP, or both 10 μM PAN-811·Cl·H₂O and one of these anticancer drugs for 3 days, respectively (n = 6). (e)–(g) LDH analysis for (b)–(d) (n = 6). Data are expressed as % of noninsulted/untreated control. Figure symbol is ##, P < 0.01, compared with noninsult/untreated control group by one-factor ANOVA followed with Tukey HSD test. §§, P < 0.01 between no insult and insult groups given PAN-811 by Student's t-test.