Table 1.
Global post-translational modifications of histones in cancer
| Histone PTM | Writer | Eraser | Function | Cancer Diagnosis/ Prognosis/ Treatment |
| H3K9ac | GCN-5 | SIRT-1; SIRT-6 | Transcription initiation | Diagnosis: ? |
| Prognosis: Lung, breast, ovarian | ||||
| Treatment: ? | ||||
| H3K18ac | CBP/p300 | ? | Transcription initiation and repression | Diagnosis: ? |
| Prognosis: Lung, prostate, breast, esophagus | ||||
| Treatment: ? | ||||
| H4K5ac | CBP/P300; HAT1; TIP60; HB01 | ? | Transcription activation | Diagnosis: ? |
| Prognosis: Lung | ||||
| Treatment: ? | ||||
| H4K8ac | TIP60; HB01 | ? | Transcription activation | Diagnosis: ? |
| Prognosis: Lung, | ||||
| Treatment: ? | ||||
| H4K16ac | TIP60; hMOF | SIRT-1; SIRT-2 | Transcription activation | Diagnosis: Colorectal |
| Prognosis: Lung, breast | ||||
| Treatment: ? | ||||
| H3K4me | SETD1A; SETD1B; ASH1L; MLL; MLL2; MLL3: MLL4; SETD7 | KDM1A; KDM1B; KDM5B; NO66 | Transcription activation | Diagnosis: ? |
| Prognosis: Prostate, kidney | ||||
| Treatment: ? | ||||
| H3K4me2 | SETD1A; SETD1B; MLL; MLL2; MLL3; MLL4; SMYD3 | KDM1A; KDM1B; KDM5A; KDM5B; KDM5C; KDM5D; NO66 | Transcription activation | Diagnosis: ? |
| Prognosis: Prostate, lung, kidney, breast, pancreatic, liver, | ||||
| Treatment: ? | ||||
| H3K4me3 | SETD1A; SETD1B; ASH1L; MLL; MLL2; MLL3; MLL4; SMYD3; PRMD9 | KDM2B; KDM5A; KDM5B; KDM5C; KDM5D; NO66 | Transcription elongation | Diagnosis: ? |
| Prognosis: Kidney, liver, prostate | ||||
| Treatment: ? | ||||
| H3K9me | SETDB1; G9a; EHMT1; PRDM2 | KDM3A; KDM3B§; PHF8; JHDM1D | Transcription initiation | Diagnosis: Myeloma |
| Prognosis: Kidney, pancreas, prostate | ||||
| Treatment: ? | ||||
| H3K9me2 | SUV39H1; SUV39H2; SETDB1; G9a; EHMT1; PRDM2 | KDM3A; KDM3B§; KDM4A; KDM4B; KDM4C; KDM4D; PHF8; KDM1A; JHDM1D | Transcription initiation and repression | Diagnosis: ? |
| Prognosis: Prostate, pancreas | ||||
| Treatment: ? | ||||
| H3K9me3 | SUV39H1; SUV39H2; SETDB1; PRDM2 | KDM3B§; KDM4A; KDM4B; KDM4C; KDM4D | Transcription initiation and repression | Diagnosis: Colorectal, myeloma, prostate, breast and lung |
| Prognosis: Lung, prostate, breast, leukemia, stomach | ||||
| Treatment: ? | ||||
| H3K27me | EZH2; EZH1 | JHDM1D | Transcription activation | Diagnosis: ? |
| Prognosis: Kidney | ||||
| Treatment: ? | ||||
| H3K27me3 | EZH2; EZH1 | KDM6A; KDM6B; | Transcription repression | Diagnosis: ? |
| Prognosis: Breast, pancreatic, ovarian, prostate, stomach, Esophagus, Liver | ||||
| Treatment: ? | ||||
| H4K20me3 | SUV420H1; SUV420H2 | ? | Transcription repression | Diagnosis: Colorectal, myeloma, prostate, breast and lung |
| Prognosis: Breast, lymphoma, colon, ovarian | ||||
| Treatment: ? |
PTM: Post translational modification.