Table 1.
Changed proteins in mdx-4cv brain tissue as revealed by label-free LC–MS/MS analysis
| Accession number | Protein name | Peptide count | Confidence score | Anova (p) | Fold change |
|---|---|---|---|---|---|
| Q91X72 | Hemopexin | 3 | 131.20 | 0.00116 | 5.64 |
| P29699 | Alpha-2-HS-glycoprotein | 2 | 125.19 | 0.00171 | 3.47 |
| P22599 | Alpha-1-antitrypsin 1-2 | 2 | 114.76 | 0.01445 | 3.29 |
| P02088 | Hemoglobin subunit beta-1 | 3 | 260.19 | 0.00104 | 3.24 |
| P01942 | Hemoglobin subunit alpha | 5 | 370.80 | 0.00021 | 3.22 |
| Q00623 | Apolipoprotein A-I | 8 | 316.96 | 0.00522 | 2.88 |
| P07758 | Alpha-1-antitrypsin 1-1 | 4 | 108.27 | 0.01739 | 2.52 |
| P07724 | Serum albumin | 16 | 1174.47 | 0.00049 | 2.51 |
| Q923D2 | Flavin reductase (NADPH) | 3 | 203.95 | 0.00171 | 2.51 |
| Q921I1 | Serotransferrin | 8 | 374.58 | 0.01661 | 2.18 |
| P03995 | Glial fibrillary acidic protein | 8 | 491.51 | 0.03531 | 2.00 |
| Q08331 | Calretinin | 2 | 94.24 | 0.04022 | 1.93 |
| P48036 | Annexin A5 | 2 | 132.70 | 0.03204 | 1.56 |
| P20152 | Vimentin | 2 | 213.31 | 0.00440 | 1.55 |
| Q9R0P9 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | 3 | 165.79 | 0.02308 | 1.51 |
| P46460 | Vesicle-fusing ATPase | 2 | 134.05 | 0.00110 | 1.44 |
| Q9D0E1 | Heterogeneous nuclear ribonucleoprotein M | 3 | 63.46 | 0.01490 | 1.44 |
| O08788 | Dynactin subunit 1 | 2 | 126.53 | 0.01025 | 1.44 |
| P38647 | Stress-70 protein, mitochondrial | 6 | 476.79 | 0.00175 | 1.42 |
| P48758 | Carbonyl reductase [NADPH] 1 | 2 | 119.09 | 0.01333 | 1.42 |
| P00920 | Carbonic anhydrase 2 | 2 | 135.96 | 0.02814 | 1.42 |
| P14733 | Lamin-B1 | 2 | 150.58 | 0.02918 | 1.41 |
| Q6IRU5 | Clathrin light chain B | 2 | 125.00 | 0.04203 | 1.40 |
| Q8R3V5 | Endophilin-B2 | 4 | 201.90 | 0.02055 | 1.39 |
| Q8QZT1 | Acetyl-CoA acetyltransferase, mitochondrial | 4 | 215.23 | 0.00680 | 1.36 |
| P27773 | Protein disulfide-isomerase A3 | 5 | 295.10 | 0.01295 | 1.35 |
| Q91VR2 | ATP synthase subunit gamma, mitochondrial | 4 | 251.82 | 0.00255 | 1.35 |
| Q6ZWY9 | Histone H2B type 1-C/E/G | 2 | 121.60 | 0.04212 | 1.34 |
| Q61171 | Peroxiredoxin-2 | 2 | 141.40 | 0.01279 | 1.33 |
| Q9D051 | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 4 | 262.12 | 0.00408 | 1.32 |
| O35737 | Heterogeneous nuclear ribonucleoprotein H | 2 | 100.27 | 0.01665 | 1.31 |
| Q03265 | ATP synthase subunit alpha, mitochondrial | 6 | 480.06 | 0.00581 | 1.30 |
| P20029 | 78 kDa glucose-regulated protein | 2 | 150.07 | 0.02510 | 1.29 |
| Q9QXS6 | Drebrin | 3 | 142.38 | 0.01934 | 1.28 |
| P62259 | 14-3-3 protein epsilon | 2 | 103.43 | 0.02864 | 1.27 |
| O88737 | Protein bassoon | 3 | 215.46 | 0.01328 | 1.25 |
| Q811D0 | Disks large homolog 1 | 2 | 110.76 | 0.00639 | 1.25 |
| P14873 | Microtubule-associated protein 1B | 2 | 126.07 | 0.00500 | 1.24 |
| P16546 | Spectrin alpha chain, non-erythrocytic 1 | 3 | 197.38 | 0.01491 | 1.24 |
| P61264 | Syntaxin-1B | 4 | 356.83 | 0.00121 | −1.28 |
| Q02053 | Ubiquitin-like modifier-activating enzyme 1 | 2 | 131.59 | 0.04436 | −1.41 |
| P51150 | Ras-related protein Rab-7a | 3 | 106.89 | 0.01101 | −1.51 |
| P07901 | Heat shock protein HSP 90-alpha | 2 | 109.14 | 0.03836 | −1.54 |
| O08599 | Syntaxin-binding protein 1 | 4 | 315.93 | 0.01966 | −1.54 |
| Q9WV92 | Band 4.1-like protein 3 | 3 | 218.67 | 0.00892 | −1.90 |
| Q9R0K7 | Plasma membrane calcium-transporting ATPase 2 | 2 | 108.25 | 0.01784 | −2.77 |