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. 2015 Nov 24;12:219. doi: 10.1186/s12974-015-0441-2

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© Yang et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Intraplantar BV injection induces up-regulation of SDF1 and CXCR4 in the rat lumbar DRG. a Representative immunofluorescence photomicrographs of SDF1 in lumbar DRG from saline-treated rats and BV-treated rats. b Quantification of the mean immunofluorescent intensity of SDF1 showing an increase in SDF1 expression following intraplantar BV injection (n = 5/group, ***P < 0.001). c Immunofluorescent photomicrographs of double-staining of the SDF1 (red) with GFAP (green), a marker for satellite glial cell. d Representative immunofluorescent photomicrographs of CXCR4 in the lumbar DRG from saline-treated rats, BV-treated rats, and rats that received AMD3100 10 min before BV injection. e Quantification of the mean immunofluorescent intensity of CXCR4 showing an increase in CXCR4 expression following intraplantar BV injection and a reduction of CXCR4 in rats that received AMD3100 10 min before injection (n = 5/group, ***P < 0.001). f Western blot showing the expression of CXCR4 in lumbar DRG from saline-treated rats, BV-treated rats, and rats that received AMD3100 10 min before BV injection. Representative bands are shown on the top, and data summary is shown on the bottom. (n = 3/group, **P < 0.01, ***P < 0.001)