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. 2015 Nov 24;12:219. doi: 10.1186/s12974-015-0441-2

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© Yang et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Blockade of BV-induced phosphorylation of ERK and up-regulation of Nav1.8 protein expression in the lumbar DRG by peripherally local injection of AMD3100. a Representative immunofluorescent photomicrographs showing expression of Nav1.8 in the lumbar DRG from saline-treated rats, BV-treated rats, and rats receiving intraplantar AMD3100 or intrathecal U0126 10 min before intraplantar BV injection. b Quantification of the mean immufluorescent intensity of Nav1.8 showing an increase in expression following intraplantar (i.pl.) BV injection, and a reduction in rats receiving AMD3100 or U0126 administration 10 min prior to BV (n = 5/group, ***P <0.001, ##P < 0.001, ††P < 0.001 vs. saline). c Western blot showing that AMD3100 prevented the BV-induced up-regulation of Nav1.8 and pERK activation in lumbar DRG from occurring (n = 3/group, ***P < 0.001 vs. saline; #P < 0.05, ###P < 0.001 vs. BV). d Western blot showing that intrathecal U0126 prevented the BV-induced up-regulation of Nav1.8 and pERK activation in lumbar DRG from occurring (n = 3/group, ***P < 0.001 vs. saline; #P < 0.05 vs. BV). e Western blot showing that intraplantar U0126 prevented the BV-induced up-regulation of Nav1.8 and pERK activation in lumbar DRG from occurring (n = 3/group, **P < 0.01, ***P < 0.001 vs. saline; #P < 0.05, ###P < 0.001 vs. BV)