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. 2015 Nov 24;12:219. doi: 10.1186/s12974-015-0441-2

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© Yang et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Effects of intrathecal administration of an ERK inhibitor, U0126, on BV-induced persistent spontaneous nociception and mechanical and thermal hyperalgesia. a Curve graphs showing the effect of U0126 on the persistent spontaneous nociception evaluated by recording the spontaneous paw flinches at each 5 min interval for 1 h immediately after intraplantar BV injection. b Column graphs showing the effect of U0126 on the mean total numbers of paw flinches averaged from the 1 h period intraplantar BV injection. c, d Exhibiting the effects of U0126 on the PWMT and PWTL measured in bilateral hindpaws of BV-treated rats. PWMT paw withdrawal mechanical threshold, PWTL paw withdrawal thermal latency; *P < 0.05, **P < 0.01, ***P < 0.001, n = 6 for each group