Table 1.
Patients characteristics
| Variable | NSCLC | Healthy subjects |
|---|---|---|
| n = 80 | n = 16 | |
| Gender n (%): | ||
| Female | 16 (20) | 3 (18.8) |
| Male | 64 (80) | 13 (81.2) |
| Age, years, median (range) | 66 (45–77) | 34 (19–77)** |
| Smoking history n (%)* | ||
| Non- smokers | 14 (17.5) | 10 (62.5) |
| Smokers | 66 (82.5) | 6 (37.5) |
| Smoking pack-years, median (range) | 30 (0–60) | 2,5 (0–50)** |
| FEV1 % of pred. median (range) | 83 (33–144) | 93 (70–114) |
| FEV1/FVC ratio % of pred., median (range) | 89 (49–123) | 107 (86–114) |
| Histological NSCLC type: | ||
| Adenocarcinoma | 38 (47.5) | _ |
| Squamous cell carcinoma | 36 (45) | |
| Large cell carcinoma | 5 (6.2) | |
| Adenosquamous carcinoma | 1 (1.2) | |
| NSCLC stage: | ||
| Stage IA | 4 (5.0) | _ |
| Stage IB | 19 (23.8) | |
| Stage IIA | 21 (26.2) | |
| Stage IIB | 5 (6.2) | |
| Stage IIIA | 28 (35.0) | |
| Stage IIIB | 3 (3.8) | |
| T status: | ||
| T1a | 2 (2.5) | _ |
| T1b | 11 (13.8) | |
| T2a | 37 (46.2) | |
| T2b | 8 (10.0) | |
| T3 | 18 (22.5) | |
| T4 | 2 (5.0) | |
| N status | _ | |
| N0 | 35 (43.8) | |
| N1 | 26 (32.5) | |
| N2 | 17 (21.2) | |
| N3 | 2 (2.5) | |
| Diferenciation: | _ | |
| Poor | 46 (57.5) | |
| Other | 33 (41.2) |
FEV 1 forced expiratory volume in one second, FVC forced vital capacity
*P < 0.05, chi-square (χ 2) test
**P < 0.05, Mann–Whitney U test