Table 3.

Slope and neuroimaging regression results by diagnostic group

					Two-slope method
NC participants	Simple slope n = 198		Regression-based n = 198		Trials 1–2 slope n = 198		Trials 2–5 slope n = 198		Peak slope n = 198
	β	p-Value	β	p-Value	β	p-Value	β	p-Value	β	p-Value
Parahippocampal gyrus thickness	–0.01	.88	–0.03	.63	0.01	.70	–0.03	.47	0.03	.47
Hippocampal volume**	0.00	.83	0.00	.52	0.00	.96	0.00	.62	0.00	.46
Precuneus thickness	0.00	.96	0.00	.92	0.00	.59	0.00	.98	0.00	.91
DLPFC thickness	–0.01	.62	–0.01	.65	0.00	.46	0.00	.86	0.00	.96
VLPFC thickness	–0.02	.23	–0.03	.14	0.00	.92	–0.03	.05	0.00	.88

					Two-slope method
MCI participants	Simple slope n = 370		Regression-based n = 370		Trials 1–2 slope n = 370		Trials 2–5 slope n = 370		Peak slope n = 361
	β	p-Value	β	p-Value	β	p-Value	β	p-Value	β	p-Value
Parahippocampal gyrus thickness	0.25	<.01*	0.27	<.01*	0.06	<.01*	0.19	<.01*	0.06	.11
Hippocampal volume**	0.02	<.01*	0.03	<.01*	0.00	.24	0.02	<.01*	0.00	.58
Precuneus thickness	0.04	.03	0.04	.02	0.01	.32	0.04	.03	0.01	.36
DLPFC thickness	0.02	.15	0.03	.05	0.00	.96	0.03	.05	0.00	.92
VLPFC thickness	0.03	.02	0.05	<.01*	0.00	.37	0.04	.01	0.01	.48

					Two-slope method
AD participants	Simple slope n = 171		Regression-based n = 171		Trials 1–2 slope n = 171		Trials 2–5 slope n = 171		Peak slope n = 155
	β	p-Value	β	p-Value	β	p-Value	β	p-Value	β	p-Value
Parahippocampal gyrus thickness	0.19	.09	0.26	.02	0.01	.72	0.21	.03	–0.05	.41
Hippocampal volume**	0.01	.40	0.01	.31	0.00	.94	0.01	.46	0.00	.88
Precuneus thickness	0.02	.68	0.04	.40	–0.01	.55	0.02	.50	−0.01	.61
DLPFC thickness	–0.01	.84	0.01	.79	0.00	.65	0.01	.79	0.00	.94
VLPFC thickness	0.03	.34	0.05	.12	0.00	.80	0.05	.14	–0.01	.49

Note. NC = normal control, MCI = mild cognitive impairment; AD = Alzheimer's disease; DLPFC = dorsolateral prefrontal cortex, VLPFC = ventrolateral prefrontal cortex

^*p< .01.

^**Hippocampal volume was corrected by intra-cranial volume.