Table 3.

ProFit-Estimated Group Mean Water-Normalized Peak Areas Together With the Corresponding Intra- and Inter-subject CVs and CRLB Values^*

Brain region	Metabolite	Inc	Metabolite/water (Mean ± SD; ×10−5)	Intra-subject CV (%)	Inter-subject CV (%)	S1 Inter-subject CV (%)	CRLB (% ± SD)
ACC	Cre	20	7.3 ± 1.0	4.5	15	16	0.5 ± 0.1
	NAA	20	10.3 ± 1.2	7.0	10	14	0.5 ± 0.1
	PCh/GPC	20	2.0 ± 0.2	4.4	9	8	3.5 ± 0.6
	Ala	20	0.3 ± 0.1	26	29	29	17 ± 10
	Asc	20	3.6 ± 0.6	6.0	16	15	2.3 ± 0.3
	Asp	20	2.0 ± 0.4	6.5	21	25	6.2 ± 1.3
	GABA	20	1.3 ± 0.4	15	24	32	5.7 ± 1.3
	Glc	20	3.2 ± 0.6	8.1	17	16	3.9 ± 0.7
	Gln	20	1.8 ± 0.3	9.9	16	16	5.9 ± 1.3
	Glu	20	8.6 ± 1.2	4.5	14	14	1.4 ± 0.2
	Gly	20	0.8 ± 0.2	13	19	22	6.2 ± 1.8
	GSH	20	1.8 ± 0.3	7.5	17	16	2.2 ± 0.3
	Ins	20	5.4 ± 0.6	3.6	11	13	1.8 ± 0.2
	Lac	20	0.6 ± 0.2	12	30	31	7.4 ± 1.3
	Tau	20	1.2 ± 0.3	26	22	24	8.3 ± 3.4
	sI	20	0.4 ± 0.1	11	37	37	4.7 ± 1.4
	NAAG	4	1.0 ± 0.8	48	82	12	7.5 ± 6.5
	PE	20	2.6 ± 0.4	8.1	16	18	4 ± 0.5
POC	Cre	20	8.4 ± 1.1	3.0	13	15	0.4 ± 0.1
	NAA	20	13.0 ± 1.4	3.2	11	13	0.3 ± 0.1
	PCh/GPC	20	1.9 ± 0.3	4.0	15	16	3.5 ± 0.7
	Ala	20	0.4 ± 0.1	11	26	27	14 ± 3.3
	Asc	20	3.7 ± 0.6	5.5	16	18	2.6 ± 0.5
	Asp	20	2. 5 ± 0.4	6.4	14	15	5.6 ± 1.5
	GABA	20	1.4 ± 0.2	8.3	13	15	5.7 ± 1.5
	Glc	20	3.5 ± 0.8	8.3	23	26	4.1 ± 0.9
	Gln	20	2.2 ± 0.3	12.5	8.6	10	5.4 ± 1.6
	Glu	20	9.3 ± 0.9	2.5	10	10	1.4 ± 0.3
	Gly	20	1.3 ± 0.3	12	21	28	4.5 ± 1.3
	GSH	20	1.8 ± 0.4	5.3	20	24	2.4 ± 0.4
	Ins	20	6.0 ± 0.7	4.3	11	13	1.8 ± 0.4
	Lac	20	0.5 ± 0.1	11	20	23	12 ± 2.8
	Tau	20	1.1 ± 0.3	22	15	23	10.9 ± 8.4
	sI	20	0.5 ± 0.1	5.9	32	33	4.1 ± 1.3
	NAAG	5	0.6 ± 0.4	**	**	57	7.0 ± 3.4
	PE	20	2.3 ± 0.6	14	23	32	5.1 ± 1.7

^*The ‘Inc’ column denotes the total number of spectra used in the final analysis that showed CRLB <20% for a given metabolite.

^**None of the ten subjects showed NAAG CRLB values <20% at both S1 and S2, thus preventing the calculation of these CV values.