Table 4.
Precedent Literature Values and Results From the Present Study Comparing Intra- and Inter-Subject CV Values Obtained for Selected Metabolites in Frontal, Parietal or Occipital Lobe Regions in Healthy Adult Subjects*
|
1H MRS Method Brain region |
Reference | B0 Voxel size scan time |
Metabolite | Intra-subject CV (%) |
Inter-subject CV (%) |
|---|---|---|---|---|---|
| 2D J-resolved Frontal Lobe | Present Study | 3.0 T 18.75 cc 16 min | Cre | 7 | 10 |
| NAA | 4 | 9 | |||
| PCh/GPC | 5 | 15 | |||
| Glu | 5 | 14 | |||
| Gln | 10 | 16 | |||
| GABA | 15 | 24 | |||
| Ins | 4 | 11 | |||
| 2D J-resolved Frontal and Parietal Lobe | 15 | 3.0 T 15 cc 7 min | Cre | ||
| NAA | 6 | 6 | |||
| PCh/GPC | 5 | 5 | |||
| Glu | 6 | 6 | |||
| Gln | 19 | 19 | |||
| GABA | 17 | 17 | |||
| Ins | 10 | 10 | |||
| 1D PRESS Frontal Lobe | 37 | 3.0 T 12 cc 4 min | Cre | 3 | - |
| NAA | 3 | - | |||
| PCh/GPC | 3 | - | |||
| Glu | 5 | - | |||
| Gln | 37 | - | |||
| GABA | 13 | - | |||
| Ins | 15 | - | |||
| 2D J-resolved Frontal Lobe | 7 | 4.0 T 8 cc 26 min | Cre | 9 | - |
| NAA | 11 | - | |||
| PCh/GPC | 8 | - | |||
| Glu | 13 | - | |||
| Gln | 23 | - | |||
| GABA | - | - | |||
| Ins | 9 | - | |||
| 2D J-resolved Occipital Lobe | 11 | 1.5 T 27 cc 35 min | Cre | 8 | - |
| NAA | 4 | - | |||
| PCh/GPC | 8 | - | |||
| GABA | 26 | - | |||
| 2D COSY Frontal Lobe | 13 | 1.5 T 27 cc 34 min | Cre | 16+ | 14+ |
| NAA | 4 | 5 | |||
| PCh/GPC | 15++ | 10++ | |||
| Glu/Gln | 6 | 7 | |||
| GABA | 22 | 17 | |||
| Ins | 10 | 10 |
*
The intra- and inter-subject measures given by Schulte et al (15) were calculated using Cre-normalized data acquired from frontal and parietal lobes, respectively.
+
Based on the raw volume calculated for the diagonal Cre resonance.
++
Based on the mean of the Cre-normalized PCh/GPC diagonal and cross peak volumes.
T = Tesla; cc = centimeter cubed; min = minutes.