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Combined effects of TERT and JAK2 MPN predisposition loci. Genotypic odds ratios for MPN in respect to the nine genotypic combinations at TERT (rs2736100) and JAK2 (rs10974944) loci are shown for (A) sporadic and familial total cohorts as well as for (B) sporadic JAK2-positive and CALR-positive subcohorts. Risk alleles are marked in red. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]
