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Schematic diagram of cell-specific Cre recombinase-induced gene inactivation and fluorescent reporter expression systems. (A) Cell-specific expression of Cre recombinase results in excision of loxP-flanked sequences leading to gene inactivation or fluorescent reporter expression. (B) Spatiotemporal regulation of Cre activity: tamoxifen (TAM) administration permits entry of the Cre-ERT2 complex into the nucleus, allowing excision of loxP-flanked sequences.
