Table 2.

Use of HEMOLEVEN in our cohort of FXI-deficient patients

Factor XI concentrate usage (n: episodes; N: patients)	Infusion dose (U kg−1)	Number of infusions	Total dose (U kg−1)	Time between infusions if >1 infusion (h) (number of infusions)
Haemorrhages* (n = 6, N = 6)	17.5 [10.8–22.0]	2.5 [1–15]	45.5 [10.8–254.2]	48 [43–96] (21 infusions)
Surgery (including caesarean section) (n = 43, N = 31)	16.9 [9.3–34.0]	2.0 [1–7]	28.9 [9.6–148.4]	48 [5–192] (50 infusions)
Invasive procedures† (n = 10, N = 8)	19.6 [10.4–25.8]	1.0 [1–2]	19.6 [10.4–50.0]	47 [47–47] (1 infusion)
Vaginal deliveries (n = 8, N = 7)	19.5 [13.1–38.7]	1.0 [1–3]	31.1 [13.1–76.5]	24 [5–48] (4 infusions)
Vaginal/caesarean deliveries combined‡ (n = 13, N = 12)	18.8 [11.6–38.7]	1.0 [1–3]	32.1 [13.1–76.5]	36 [5–77] (8 infusions)
All (n = 67, N = 44)	18.0 [9.3–38.7]	1.0 [1–15]	26.4 [9.6–254.2]	48 [5–192] (76 infusion)

Results are expressed as median values with range in parentheses. N represents the number of patients and n represents the number of episodes.

^*Bleeding symptoms reported during or after procedures without haemostatic cover [port-a-cath installation (1), caesarean section (1), postdelivery haemorrhage (1)] and spontaneous or trauma-induced bleeding [gastrointestinal tract haemorrhage (1), retroperitoneal haematoma (1), posttrauma elbow haemarthrosis (1)].

^†Oesogastroscopy + colonoscopy (1), colonoscopy (1), bone marrow biopsy (2), drain mobilization (2), knee arthroscopy (1), ventriculography (1), epidural catheter ablation (1), knee infiltration (1).

^‡13 separate childbirths including five caesarean section and eight vaginal deliveries.