TABLE II.

Multivariate Analysis of Risk Factors in Patients With Pediatric Low-Grade Glioma

	Death due to disease		Death from non-disease causes
Factor (reference level)	HR (95% CI)	P-value	HR (95% CI)	P-value
Beam radiation, with or without implants or isotopes (no radiation)	3.9 (3.0, 4.9)	<0.0001	2.4 (1.4, 3.9)	0.0006
Degree of radiation unknown (no radiation)	3.1 (1.7, 5.8)	0.0003	NA	1.0
Primary site (cerebellum)	2.3 (1.6, 3.2)	<0.0001	NA	1.0
Histology group (pilocytic astrocytoma)	2.2 (1.7, 2.8)	<0.0001	NA	0.05
Age of diagnosis (≥2 years old)	2.0 (1.5, 2.8)	<0.0001	2.2 (1.1, 4.5)	0.03
Subtotal resection, biopsy or no resection (total resection)	1.5 (1.01, 2.1)	0.04	3.0 (1.1, 8.6)	0.04

HR, hazard ratio (increased risk of death due to disease for the Factor in comparison to the reference level); CI, confidence interval.