FIG. 1.

Spatial variations in shear stress differentially increased p62 accumulation in rabbit aorta. (A) Cross section in rabbit aorta highlights instantaneous spatial variations in WSS in the aortic arch versus descending aorta during systole. The instantaneous WSS is low in the lesser curvature of aortic arch, but is circumferentially high in the descending aorta. Immunohistochemistry reveals more prominent p62 staining in the lesser curvature of aortic arch (B) where ECs were exposed to disturbed flow, including OSS, when compared with the descending aorta (C) where ECs were exposed to PSS. ECs, endothelial cells; OSS, oscillatory shear stress; PSS, pulsatile shear stress; WSS, wall shear stress. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars