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. 2015 Nov 20;23(15):1207–1219. doi: 10.1089/ars.2014.5896

FIG. 7.

FIG. 7.

Antioxidants and JNK inhibitor reversed OSS-induced mtDNA damage. (A) HAECs were infected with control or recombinant MnSOD adenovirus (MOI 1:100) overnight, and then were exposed to OSS for 4 h. MnSOD overexpression significantly reversed OSS-induced mtDNA damage (p<0.05, n=4). (B) HAECs were exposed to static condition or OSS for 4 h in the presence or absence of 5 mM of antioxidant (NAC) or (C) 10 μM of JNK inhibitor, SP600125 (SP). Both NAC and SP significantly reversed OSS-induced mtDNA damage (NAC: p<0.05; SP: p<0.01, n=4).