Table 2.

Common Incident Conditions in P1074 Participants and Their Relationships to CD4 Levels at Study Entry

Conditiona	Participants at Risk, No.	Events, No.	Total Person-Years	IR/100 Person-Years	P Valueb
Broad categories of conditions
Genital tract infections	961	128	3760	3.405	.008
Psychiatric disorders	1061	124	4492	2.760	.10
Neurodevelopmental disorders	816	41	3520	1.165	.054
Specific conditions
Infectious conditions
Pneumonia	811	41	3508	1.169	<.001
Zoster	1042	35	4599	0.761	<.001
Oropharyngeal candidiasis	840	27	3732	0.723	<.001
Nongenital herpes simplex virus	1064	31	4724	0.656	<.001
Cellulitis	1082	24	4801	0.500	.002
Esophageal or pulmonary candidiasis	1160	23	5185	0.444	<.001
Latent tuberculosis	1196	21	5345	0.393	.52
Genital tract infections
HPV	1024	79	4155	1.901	.006
Organism not specified	1035	48	4286	1.120	.003
Chlamydia	1064	36	4462	0.807	.66
Anogenital herpes simplex virus	1069	24	4502	0.533	<.001
Candidiasis	1064	19	4498	0.422	.18
Syphilis	1080	17	4571	0.372	.19
Gonorrhea	1072	16	4546	0.352	.25
Trichomoniasis	1072	16	4540	0.352	.33
Pregnancy	512	97	1896	5.117	.32
Psychiatric and neurodevelopmental disorders
Mood disorders	1092	102	4696	2.172	.04
Learning and communication disorders	962	44	4170	1.055	.002b
Anxiety disorders	1172	38	5195	0.731	.80
Substance or alcohol abuse	1186	24	5290	0.454	.53
Trauma and stress-related disorders	1189	16	5318	0.301	.57
Other conditions
Asthma	884	47	3844	1.223	.78
Iron deficiency anemia	1145	39	5076	0.768	<.001
Hypertension	1156	34	5147	0.661	.003
Eczema	1019	25	4501	0.555	.74
Vitamin D deficiency/metabolic bone disorders	1179	25	5281	0.473	.29
Renal disease	1162	24	5186	0.463	.54
Gastroesophageal reflux disease	1161	19	5195	0.366	.07
Lipodystrophy	1140	19	5089	0.373	.20
Neutropenia	1044	16	4644	0.345	.68
Dyslipidemia	1174	18	5242	0.343	.06
Wasting/failure to thrive	1031	15	4616	0.325	<.001
Fractures	1183	17	5311	0.320	.75
Hepatitis, nonspecific	1153	16	5151	0.311	.06

Abbreviations: HPV, human papillomavirus; IRs, incidence rates.

^a IRs for all infectious and noninfectious conditions were calculated, and conditions with IRs >0.3 per 100 person years are included; conditions are defined in greater detail in Supplementary Text 1.

^b P value for trend test computed from Poisson regression model comparing IRs across increasing baseline CD4 cell count categories of 0–199, 200–349, 350–499, and ≥500 cells/mm³; all significant increases reflect higher IRs with lower CD4 cell counts with the exception of learning and communication disorders. (Additional details, including IRs by baseline CD4 cell count, are provided in Supplementary Table 2).