Table 3.

Characteristics of 14 Patients With Post-Treatment Lyme Disease Symptoms Prospectively Followed for 11–20 Years

Case No.	Age at Baseline (y)	Sex	EM	No. of Symptoms at Baseline	Persistent Symptomsa	Onset of Persistent Symptoms	Duration of Persistent Symptoms	Duration of Follow-up	Serology at Last Visit
1	50	M	S	3	Fatigue, cognitive	Baseline	Fatigue 15 y Cognitive 15 y	16 visits over 15 y	Reactive C6
2	54	F	S	5	Fatigue	Baseline	3 y	18 visits over 18 y	Negative C6
3	55	F	Mlt	4	Headache	Baseline	1 y	13 visits over 17 y	Negative C6
4	57	F	Mlt	5	Fatigue, cognitive, paresthesia/numbness	Fatigue and cognitive at baseline paresthesia/ numbness after baseline visit	13 y	14 visits over 13 y	Reactive C6
5	40	F	S	7	Cognitive	Baseline	14 y	13 visits over 16 y	Negative C6
6	45	F	S	0	Cognitive, stiff neck, joint pains	After baseline visit	≤6 y	11 visits over 13 y	Not done
7	42	F	Mlt	7	Cognitive, stiff neck, joint pains, fatigue, headache	Baseline except cognitive	Variable; only cognitive lasted until year 18	7 visits over 18 y	Reactive WCS EIA
8	37	M	S	3	Fatigue	Baseline	1 y	14 visits over 19 y	Negative C6
9	49	M	Mlt	2	Paresthesia/numbnessb	After baseline visit	2 y	7 visits over 11 y	Negative C6
10	72	F	S	4	Fatigue, cognitive	Fatigue at baseline Cognitive after baseline	11 y	12 visits over 11 y	Negative C6
11	45	M	Mlt	9	Cognitive	Baseline	16 y	14 visits over 16 y	Negative C6
12	43	M	Mlt	6	Joint pain	Baseline	20 y	16 visits over 20 y	Reactive C6
13	55	M	S	8	Numbnessb	Baseline	3 y	7 visits over 13 y	Negative C6
14	70	M	S	2	Balance problemsb	Baseline	13 y	14 visits over 14 y	Negative WCS EIA

Abbreviations: EIA, enzyme immunoassay; EM, erythema migrans; Mlt, multiple; S, single; WCS, whole-cell sonicate.

^a Cognitive indicates memory or concentration difficulties.

^b Symptom may have been due to focal nerve injury.