Table 4.

Microbiologic Findings and Treatment of 14 patients With Post-Treatment Lyme Disease Symptoms Followed for 11–20 Years

Case No.	Skin Culture Result	Blood Culture Result	Baseline Treatment for Lyme Disease	Retreatment Directed at Persistent Symptoms	Recurrence of Erythema Migrans	Intercurrent Antibiotics Active Against Borrelia burgdorferi Prescribed for Other Reasons
1	RST3, OspC I	Neg	Doxy ×14 d	None	No	Yes
2	RST3, OspC M	Neg	1 dose CTX; Doxy ×10 d;	None	No	Yes
3	RST1 and RST2, OspC- nd	Neg	Doxy ×10 d	None	Yes at 2 y into f/u	Yes
4	RST3, OspC E	RST3, OspC E	Doxy ×14 d	None	Yes at 11 y into f/u	Yes
5	RST1, OspC B	RST1, OspC B	CTX ×8 d; Doxy ×14 d	Yes doxy ×28 d at 1 y	No	Yes
6	RST1, OspC B	Neg	Doxy ×14 d	Yes, twice with doxy during the first 6 mo	No	Yes
7	RST1, OspC A	Neg	Azithro ×7 d	Yes, twice- doxy ×14 d at 2 mo and CTX ×14 d at 1 y	No	Yes
8	RST3, OspC D	Neg	1 dose CTX; Doxy ×10 d	None	No	Yes
9	RST2, OspC K	Neg	Doxy ×14 d	None	No	No
10	RST1 and RST2, OspC- nd	RST1, OspC B	Doxy ×14 d	None	No	Yes
11	RST2, OspC K	RST2, OspC K	CTX ×4 d; Doxy ×14 d	Yes × multiple times	No	Yes
12	RST1, OspC nd	Neg	Amox ×20 d	None	No	Yes
13	RST3, OspC I	RST3, OspC I	Doxy ×14 d	None	No	No
14	RST1, OspC A	Neg	Doxy ×20 d	None	No	Yes

Abbreviations: Amox, amoxicillin; Azithro, azithromycin; CTX, ceftriaxone; Doxy, doxycycline; f/u, follow-up; nd, not done; Neg, negative; OspC, outer surface protein C; RST, ribosomal spacer type.