Table 1.

Pol II insertions (I-VII) and their interactions with GTFs and Mediator

Group	Insertions	Domains having these insertions	Binding factors	References
I	i3, i4, i8, i26, and i27	Foot and cleft (Rpb1), N- and C- terminal tails (Rpb6)
II	i5, i6, and i7	Jaw (Rpb1)	TFIIH	28
III	i2 and i25	Clamp head (Rpb1) and jaw (Rpb5)
IV	i10, i15, i16, and i17	External 1 (Rpb2)
V	i11, i12, i13, and i14	protrusion, lobe and fork (Rpb2)	TFIIF	26
VI	i18, i19, i20, i21, i22, i28, i29, and i30	Domain 2 and tail (Rpb3), N-and C-terminal tails (Rpb11) and zinc ribbon (Rpb12)	Mediator	23
VII	i1, i9, i23, and i24	Clamp core and CTD (Rpb1), tip- associated (Rpb4)	Mediator	27