Skip to main content
. 2015 Sep 4;64(12):4298–4311. doi: 10.2337/db15-0066

Figure 1.

Figure 1

Half deficiency of Klotho in KL+/− mice exacerbated the development of T1DM induced by STZ. KL+/− and WT male mice were injected with STZ or citrate buffer. Blood glucose levels, glucose tolerance, insulin sensitivity, and plasma insulin levels were measured during the 5-week period. Fasting blood glucose levels (A). GTT results at week 2 (B) and week 4 (D) after the initial STZ injections. Area under the curve for GTT results at week 2 (C) and week 4 (E) after the initial STZ injections. Original readings of IST results at week 5 (F) after the initial STZ injections. Normalized blood glucose levels of IST results at week 5 (G) after the initial injections. Plasma insulin levels at week 5 after the injections (H). Urine glucose levels after the injections (I). Data = mean ± SEM. n = 4–8 animals/group. **P < 0.01 and ***P < 0.001 vs. the WT group; +P < 0.05 and ++P < 0.01 vs. the WT-STZ group.