Table 2. Frequency of immune reconstitution inflammatory case-defining events in HIV Outpatient Study, United States, 1996–2007 (N = 370).
| IRIS-defining condition | N | % | Type of condition |
|---|---|---|---|
| Candidiasis, any | 85 | 23.0 | - |
| Oral | 64 | 17.3 | B |
| Esophageal | 15 | 4.1 | C |
| Vaginal | 6 | 2.0 | MC |
| Folliculitis | 51 | 13.8 | MC |
| Herpes simplex infection, any | 37 | 12.4 | - |
| Genitourinary | 21 | 5.7 | MC |
| Anorectal | 16 | 4.3 | MC |
| Condyloma, any | 45 | 12.2 | MC |
| Genitourinary | 27 | 7.3 | MC |
| Anorectal | 18 | 4.9 | MC |
| Tinea | 41 | 11.1 | MC |
| Molluscum contagiosum, any | 24 | 6.5 | MC |
| Cutaneous | 23 | 6.2 | MC |
| Genitourinary | 1 | 0.3 | MC |
| Mycobacterial disease, any | 15 | 4.1 | - |
| Disseminated Mycobacterium avium complex |
12 | 3.2 | C |
| Atypical mycobacterial infection | 2 | 0.5 | C |
| Mycobacterium tuberculosis infection |
1 | 0.3 | C |
| Cytomegalovirus infection, any | 13 | 3.5 | C |
| Colonic | 4 | 1.1 | C |
| Retinal | 5 | 1.4 | C |
| Esophagitis | 1 | 0.3 | C |
| Other | 3 | 0.8 | - |
| Pneumocystis pneumonia | 10 | 2.7 | C |
| Kaposi’s sarcoma, any | 9 | 2.4 | C |
| Cutaneous | 8 | 2.2 | C |
| Gastrointestinal | 1 | 0.3 | C |
| Zoster | 9 | 2.4 | B |
| Non-Hodgkin’s lymphoma | 8 | 2.2 | C |
| Wasting syndrome | 6 | 1.6 | C |
| Cryptococcal disease, any | 4 | 1.1 | C |
| Meningitis | 2 | 0.5 | C |
| Systemic | 2 | 0.5 | C |
| Toxoplasmosis | 3 | 0.8 | C |
| Cryptosporidiosis | 3 | 0.8 | C |
| Histoplasmosis | 2 | 0.5 | C |
| Pelvic inflammatory disease | 2 | 0.5 | C |
| Progressive multifocal leukoencephalopathy |
2 | 0.5 | C |
| Idiopathic thrombocytopenic purpura |
1 | 0.3 | B |
Conditions presented in order of decreasing frequency of the main category. B and C represents type B-defining or type C-defining diagnoses (per 1993 surveillance case definition for HIV/AIDS). IRIS, immune reconstitution inflammatory; MC, mucocutaneous condition.