Table 4.

Proportion of globally sclerotic and transitional glomeruli per age group observed in Glepp1-peroxidase sections (n=89)

Variable	Age <19 yr (Column A)	Age 19–45 yr (Column B)	Age 46–60 yr (Column C)	Age >60 yr (Column D)
Glomeruli evaluated (n)	419	648	1682	2788
FGGS (%)	0.4±1.2a	0.0+0.0b	1.8±3.9b	5.7±6.2c
Transitional glomeruli (%)	0.5±1.6a	0.7±1.7a	3.8±5.0d	5.5±7.0d
Podocyte mass detachment events (%)	0.0±0.0	0.0±0.0	0.3±1.1	0.2±0.4
Podocyte glycocalyx detachment (%)	0.0±0.0	0.0±0.0	0.7±1.8	0.8±1.2

Values expressed with a plus/minus sign are the mean±SD. FGGS was defined according to Figure 6I. Transitional glomeruli were defined according to Figure 6, B–F. Transitional glomeruli were any glomerulus that had proteinaceous material and/or detached cells in the Bowman space. Podocyte mass detachment events contained at least three detached Glepp1-positive cells in the Bowman space. Podocyte glycocalyx detachment events contained definitely Glepp1-positive material in the proteinaceous cast in the Bowman space, as shown in Figure 7.

^aP<0.05 vs. columns C and D.

^bP<0.05 vs. column D.

^cP<0.05 vs. columns A, B, and C.

^dP<0.05 vs. columns A and B.