Table 6.
Pathologic characteristics associated with MPDEs
| Patient | Foot Process Effacement | Podocyte Density | Glomerular Number | FGGS (%) | FSGS (%) | MPDE (%) | PGDE (%) | Ischemic (%) | |
|---|---|---|---|---|---|---|---|---|---|
| per 106 μm3 | Normal (%) | ||||||||
| 1 | Focal | 153 | 48 | 22 | 31.8 | 0.0 | 13.6 | 0.0 | 0.0 |
| 2 | Partial artial | 142 | 45 | 26 | 19.2 | 0.0 | 3.8 | 3.8 | 0.0 |
| 3 | ND | 129 | 61 | 24 | 50.0 | 0.0 | 12.5 | 0.0 | 0.0 |
| 4 | ND | 82 | 54 | 33 | 9.1 | 0.0 | 6.1 | 0.0 | 0.0 |
| 5 | >90% | 153 | 48 | 27 | 18.5 | 0.0 | 7.4 | 11.1 | 0.0 |
| Mean±SD | 131.8±29.5 | 51.2±6.4 | 26.4±4.2 | 25.9±21.4 | 0.0 | 8.7±3.4 | 3.7±6.4 | 0.0 | |
In all five biopsy specimens, the Bowman space contained multinucleate podocytes as judged by TLE4 immunostaining with DAPI counterstain to identify nuclei (Figure 9). PGDE, podocyte glycocalyx detachment event; ND, not done.