Table 2.
Complications among pregnancies with and without AKI-D
| Complication, n (%) | AKI-D n=188 | No AKI-D n=1,918,601 | P Valuea |
|---|---|---|---|
| Multifetal gestation | ≤5 (≤2.7) | 31,255 (1.6) | 0.97 |
| Cesarean delivery | 81 (43.1) | 488,820 (25.5) | <0.001 |
| Medical complicationsb | |||
| Hyperemesis gravidarum | 11 (5.9) | 77,107 (4.0) | 0.20 |
| Diabetes mellitusc | 13 (6.9) | 45,615 (2.4) | <0.001 |
| Gestational hypertension | 6 (3.2) | 34,619 (1.8) | 0.15 |
| Preeclampsia | 40 (21.3) | 99,686 (5.2) | <0.001 |
| Thrombotic microangiopathyd | 25 (13.3) | 8143 (0.4) | <0.001 |
| Pregnancy-related liver diseasee | ≤5 (≤2.7) | 1475 (0.1) | <0.001 |
| Heart failure | 30 (16.0) | 2665 (0.1) | <0.001 |
| Pyelonephritis | 6 (3.2) | 13,585 (0.7) | <0.001 |
| Sepsis | 34 (18.1) | 6252 (0.3) | <0.001 |
| Amniotic fluid embolism | ≤5 (≤2.7) | 39 (0.0) | <0.001 |
| Placenta previa | ≤5 (≤2.7) | 10,275 (0.5) | 0.05 |
| Placental abruption | 9 (4.8) | 46,242 (2.4) | 0.03 |
| Postpartum hemorrhage | 33 (17.6) | 63,144 (3.3) | <0.001 |
| Any of the above medical complications | 130 (69.2) | 719,973 (37.5) | <0.001 |
To comply with privacy regulations for minimizing the chance of identification of a study participant, numbers of participants are suppressed in the case of five or fewer participants (reported as ≤5).
P values were derived from two-sample t-tests when comparing continuous variables and from chi-squared tests when comparing categorical variables.
Medical complications were ascertained from administrative database codes during pregnancy and the peripartum period.
Diabetes mellitus includes preexisting type 1 diabetes mellitus, preexisting type 2 diabetes mellitus, and gestational diabetes.
Thrombotic microangiopathy includes HELLP syndrome and thrombotic thrombocytopenic purpura. Eight of the 25 patients in the AKI-D group were also treated with plasma exchange.
Pregnancy-related liver disease includes unspecified liver and biliary diseases in pregnancy.