Skip to main content
. 2015 Aug 20;26(12):2989–3000. doi: 10.1681/ASN.2014100978

Figure 5.

Figure 5.

Post-IR changes in kidney-infiltrating immune cells and cytokine production in CD4-Keap1-KO and Keap1F/F mice. (A) There is a significantly higher percentage of Tregs (P=0.04) and a lower percentage of CD11b+CD11c+ (P=0.02) and F4/80+ (P=0.03) cells in kidneys of CD4-Keap1-KO mice 24 hours after the induction of AKI. (B) Absolute numbers of Tregs (343.30±102.5 versus 284.1±80.9) and CD11b+CD11c+ (6.4×104±1.8×103 versus 8.3×104±3.2×103) and F4/80+ (1×105±4.1×103 versus 1.8×105±9.1×103) cells are not different between CD4-Keap1-KO and Keap1F/F mice at 24 hours after IR injury. (C) Intracellular IL-17 levels are higher in CD4, CD8, and DNT cells isolated 24 hours after IR from kidneys of CD4-Keap1-KO mice, whereas there is no difference in TNF-α and IFN-γ production. IRI, ischemia reperfusion injury. Data represent the mean±SD. *P≤0.05.