Table 2.
Association between FGF1, its renal mRNAs and blood pressure in TRANSLATE Study—next-generation RNA-sequencing analysis of human kidneys
| mRNA | Systolic BP | Diastolic BP | ||
|---|---|---|---|---|
| β-coefficient (SEM) | P value | β-coefficient (SEM) | P value | |
| FGF1 total | 0.85±0.35 | 0.021 | 1.15±0.57 | 0.053 |
| FGF1–001 | 0.91±0.36 | 0.016 | 1.21±0.58 | 0.046 |
| FGF1–003 | 0.091±0.034 | 0.0083 | 0.13±0.06 | 0.028 |
| FGF1–006 | 0.13±0.05 | 0.016 | 0.14±0.08 | 0.092 |
Data are β-coefficients, SEM and level of statistical significance (P value) from linear regression models whereby clinic BP (adjusted for treatment) was a dependent variable, and mRNA expression level (in transcripts per million units) of total FGF1 or its individual mRNAs, age, sex and body mass index were independent parameters.