Table 2.
The Associations of Incident Postmenopausal Breast Cancer Risk with Metabolic Health Defined by HOMA-IR or Insulin Levels, Stratified by Body Mass Index (BMI) Category
|
HOMA-IR based definition of Metabolic Health
| |||||
|---|---|---|---|---|---|
| BMI Category | N (Cases/Controls) | Age-adjusted HR (95% CI) | P-Value | Multivariate HR† (95% CI) | P-Value |
| Normal Weight (<25Kg/M2) | |||||
| Metabolically Healthy1 | 113/356 | 1.00 (Referent) | 1.00 (Referent) | ||
| Metabolically Unhealthy2 | 18/182 | 1.68 (0.85-3.33) | 0.13 | 1.80 (0.88-3.70) | 0.11 |
| Overweight (≥25 Kg/M2) | |||||
| Metabolically Healthy1 | 87/339 | 0.93 (0.64-1.34) | 0.68 | 0.96 (0.64-1.42) | 0.83 |
| Metabolically Unhealthy2 | 169/1238 | 1.60 (1.12-2.28) | 0.01 | 1.76 (1.19-2.60) | 0.005 |
|
| |||||
|
Insulin based definition of Metabolic Health
| |||||
| BMI Category | N (Cases/Controls) | Age-adjusted HR (95% CI) | P-Value | Multivariate HR (95% CI) | P-Value |
| Normal Weight (<25Kg/M2) | |||||
| Metabolically Healthy3 | 108/352 | 1.00 (Referent) | 1.00 (Referent) | ||
| Metabolically Unhealthy4 | 19/180 | 1.86 (0.95-3.65) | 0.07 | 2.06 (1.01-4.22) | 0.048 |
| Overweight (≥25 Kg/M2) | |||||
| Metabolically Healthy3 | 86/329 | 0.93 (0.64-1.35) | 0.71 | 0.96 (0.64-1.42) | 0.82 |
| Metabolically Unhealthy4 | 175/1250 | 1.86 (1.30-2.66) | 0.001 | 2.01 (1.35-2.99) | 0.001 |
1
HOMA-IR (quartile 1);
2
HOMA-IR (quartiles 3+4);
3
Insulin (quartile 1);
4
Insulin (quartiles 3+4); Adjusted for age, ethnicity, age at menarche and menopause, parity, first degree relative with breast cancer, education, alcohol consumption, physical activity, which of the two WHI studies each subject was enrolled in and, among those who participated in the clinical trials, which specific clinical trial arm they were assigned to and whether they were a member of the placebo or treatment group.