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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: J Huntingtons Dis. 2015;4(1):17–36.

Fig. 4.

Fig. 4

Increase in plasma levels of KC and leptin in BAC-225Q mice. The levels of seven HD-associated blood markers were measured in plasma of BAC-225Q mice. IL-4 and MIP2 are below detection limit, for IFNγ, IL-6 and TNFα no differences are found between BAC-225Q and WT mice, but levels of pro-inflammatory chemokine, KC (mouse homologue of human IL-8), and of energy metabolism-regulating hormone, leptin, are altered (n=12-18, n=12–17, respectively, gender balanced). (A) Plasma concentrations of KC are elevated in 10-month-old BAC-225Q animals (*t-test, p=0.014). (B) Leptin levels are increased in BAC-225Q mice at 6, 8 and 10 months of age (*t-test, p<0.001, p=0.002, p=0.038, respectively).