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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: J Huntingtons Dis. 2015;4(1):17–36.

Fig. 5.

Fig. 5

Progressive loss of brain volume in BAC-225Q mice. Brain volumes were measured using MRI volumetric analysis in BAC-225Q mice at 3 and 10 months of age (n=4). (A) Total brain volume (*t-test, p=0.039) and volumes of 13 out of 27 analyzed brain regions (*t-test, p<0.05) are decreased in BAC-225Q mice compared to WT littermates at 3 months of age. (B) At 10 months of age a loss of total brain volume is more prominent (*t-test, p=0.001) and 19 brain regions with decreased volumes (*t-test, p<0.05) are identified.