(A) Total average thresholds at day 0, week 1 and week 2. Radiation: animals received 3000 cGy in each ear. Non-treated animals (red bars), animals treated with intra-peritoneal injection of PrC-210 (blue bars), animals treated with intra-tympanic injection of PrC-210 (yellow bars). (B) Hearing thresholds shift for the left and right ears of irradiated adult guinea pigs not treated with PrC-210 (Red) and treated by intra-peritoneal injection of PrC-210 (Blue). Total average hearing loss in dB at week 1 (light blue and light red bars) and week 2 (dark blue and dark red bars). (C) ABR pure tone thresholds of irradiated adult guinea pigs treated by an intra-peritoneal or intra-tympanic injection of PrC-210. Average pure tone thresholds at day 0, week 1 and week 2 measured at 8kHz, 16kHz and 32kHz. Radiation (Rad): animals received 3000 cGy in each ear. IP: intra-peritoneal injection of PrC-210 (blue triangles), IT: intra-tympanic injection of PrC-210 (inverted yellow triangles). Non-treated animals are indicated with red squares. Decibels (dB), *, p< = 0.05; **, p< = 0.01; ***, p< = 0.001, n.s., non significant.