Fig 7. Proposed model for induction of systemic CD8⁺ T cell-mediated local and systemic tumor control by pre-resectional RFA.

Pre-resectional RFA reportedly promotes delivery of tumor-antigen (Ag)-loaded antigen-presenting cells such as dendritic cells (DC) to tumor-draining lymph nodes. This, in turn, is proposed to result in activation and expansion of CD8⁺ effector T cells (T_eff) which execute cytotoxic functions leading to improved local and distant tumor control after excisional surgery.