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. 2015 Nov 23;10(11):e0143413. doi: 10.1371/journal.pone.0143413

Fig 3. Impact on liver injury repair process by depletion of infiltrating hepatic macrophages during the recovery phase.

Fig 3

(A) Hepatic expression of IL-1β, IL-10, and CCL2 are significantly decreased (clodronate liposome injection group [n = 3, only survival] vs. PBS injection group [n = 4)]). Values are mean ± SEM. * P < 0.05 (Mann-Whitney U test)). (B) Collagen deposition and α-SMA expression are decreased (original magnification, x400). (C) Hepatic expression of TGF-β, Col1α1, and MMP-13 are significantly decreased (clodronate liposome injection group [n = 3, only survival] vs. PBS injection group [n = 4]). Values are mean ± SEM. * P < 0.05 (Mann-Whitney U test)).