Skip to main content
. 2015 Nov 23;10(11):e0143413. doi: 10.1371/journal.pone.0143413

Fig 7. Effects of Gpnmb expression on hepatic macrophages.

Fig 7

In infiltrating hepatic macrophages isolated from injured livers, (A) co-culture with apoptotic hepatocytes does not affect mRNA expression of Gpnmb, TGF-β, or MMP-13, but does increase TGF-β and MMP-13 secretion. Values are mean ± SEM (n = 3). * P < 0.05 (Mann-Whitney U test). Moreover, (B) mRNA expression of TGF-β and MMP-13 is not affected by inhibited Gpnmb expression, however secretion of MMP-13, but not TGF-β is significantly decreased by inhibition of Gpnmb expression. Values are mean ± SEM (n = 3). * P < 0.05 vs. control (Tukey’s HSD test).