Table 2. Significant signals of association from genome-wide and exome chip association analyses in IRASFS.
SNP | Chr: Position (hg19) | Gene | Alleles f | N | MAF e | Beta+/-SE | P-Value |
---|---|---|---|---|---|---|---|
Body Mass Index (BMI) | |||||||
rs34218846 b | 2:209108317 | IDH1 | T/C | 1253 | 0.070 | -0.10±0.020 | 4.81E-08 c |
Waist Circumference (WAIST) | |||||||
rs34218846 b | 2:209108317 | IDH1 | T/C | 1257 | 0.068 | -0.080±0.010 | 1.62E-08 c |
Waist-Hip Ratio (WHR) | |||||||
rs1471880 a | 4:113546107 | ZGRF1 | C/A | 1034 | 0.48 | -0.027±0.0047 | 1.00E-08 c |
rs13144672 a | 4:113472958 | ZGRF1 | C/T | 1034 | 0.47 | 0.027±0.0048 | 3.15E-08 d |
rs12054518 a | 4:113549989 | ZGRF1 | A/G | 1034 | 0.48 | 0.027±0.0048 | 3.23E-08 d |
rs7696816 a | 4:113539969 | ZGRF1 | C/T | 1034 | 0.48 | 0.027±0.0048 | 4.35E-08 d |
aSNP identified from GWAS
bSNP identified from exome chip
cDominant Model
dRecessive Model
eMinor allele frequency based on the entire population
fMinor/Major allele on the positive strand