Table 2. Concentration-response effect of confirmed hit-compounds.
| Compound ID | Compound Name | EC50 | Emax ± SEM |
|---|---|---|---|
| Agonists | |||
| 1388 | 5-Methoxytryptamine | 7.43e-07 | 90.92 ± 8.1 |
| 3005837 | Pyrithione Zinc | 1.65e-06 | 17.43 ± 0.88 |
| 1150 | Tryptamine | 3.08e-06 | 10.29 ± 2.36 |
| 41684 | Nitazoxanide | 4.20e-06 | 26.9 ± 1.05 |
| 54680693 | Pyrvinium Pamoate | 5.68e-06 | 22.58 ± 0.99 |
| 5649 | Valinomycin | 6.49e-06 | 8.72 ± 1.55 |
| 5265 | Spiperone | 1.02e-05 | 81.89 ± 3.48 |
| 34312 | Oxycarbazepine | 1.10e-05 | 7.44 ± 0.3 |
| 8397 | Xanthopterin | 1.13e-05 | 24.78 ± 3.04 |
| 3598 | Hexachlorophene | 1.39e-05 | 17.79 ± 2.81 |
| 3397 | Flutamide | 2.19e-05 | 15.23 ± 0.74 |
| 5701996 | Isoreserpine | 3.03e-05 | 11.53 ± 1.24 |
| 3386 | Fluoxetine | 4.45e-05 | 21.65 ± 8.32 |
| 4993 | Pyrimethamine | 5.56e-05 | 85.64 ± 2.4 |
| Antagonists | |||
| 3037 | Dichlorophene | 9.44e-07 | 115.28 ± 7.43 |
| 37123 | Diflubenzuron | 9.93e-07 | 35.15 ± 2.99 |
| 52897276 | 7-Desacetoxy-6,7-Dehydrogedunin | 1.07e-06 | 33.83 ± 6.85 |
| 16682730 | Phenylmercuric Acetate | 1.13e-06 | 112.88 ± 3.41 |
| 6083 | Adenosine 5’-monophosphate | 1.16e-06 | 49.74 ± 9.49 |
| 27924 | Phorbol Myristate Acetate | 1.27e-07 | 103.43 ± 1.94 |
| 10205 | Plumbagin | 1.50e-06 | 114.4 ± 3.67 |
| 3352 | Fipronil | 1.70e-06 | 80.65 ± 8.95 |
| 3606 | Hexestrol | 3.36e-06 | 108.18 ± 0.72 |
| 2333 | Benzbromarone | 1.91e-06 | 130.03 ± 0.19 |
| 6377243 | Obtusaquinone | 2.83e-06 | 114.15 ± 8.08 |
| 72385 | Nonoxynol-9 | 4.48e-06 | 123.35 ± 5.55 |
| 3492326 | Dihydromunduletone | 5.03e-06 | 122.17 ± 4.87 |
| 452550 | Tyrothricin | 7.19e-06 | 139.95 ± 13.1 |
| 9556529 | Oxiconazole Nitrate | 7.44e-06 | 80.33 ± 6.91 |
| 3651377 | MK-886 | 7.92e-06 | 152.43 ± 0.93 |
| 2378 | Bifonazole | 8.66e-06 | 61.95 ± 2.77 |
| 4499 | Nisoldipine | 9.43e-06 | 144.42 ± 1.97 |
| 2330 | Benzalkonium Chloride | 9.82e-06 | 115.68 ± 4.9 |
| 3503 | Gossypol | 1.00e-05 | 119.51 ± 0.7 |
| 73357 | Gramicidin | 1.08e-05 | 63.77 ± 4.03 |