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Determining the levels of JCV DNA replication supported by plasmids containing mutations within the NF-1A binding sites. A. The locations (in red) of the NF-1A binding site within the archetype (line 1) and “Δ1/2enhancer” (line 2) enhancer sequences (Frisque et al., 1984). B. The relative levels of JCV DNA replication obtained at 48 and 72 h with the parental pFL-JCVori and pFL-JCVori (Δ1/2enhancer) plasmids and the derivatives containing mutations in the NF-1A binding sites (Fig. 7A).
