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. 2015 Nov 23;10(11):e0142943. doi: 10.1371/journal.pone.0142943

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© 2015 Yasuda et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 8 — Mdm20 (magenta) is required for actin (green) cable stabilization through the N-acetylation of Trpm (light blue), which is mediated by NaB activity and involved in vacuole inheritance through actin-Trpm fibers. However, the present data show that Mdm20 deficiency suppresses mTORC2 activity by reducing Rictor (orange) expression, which may be regulated during de novo protein synthesis by the Nat5 (blue)-independent pathway. Because mTORC2 activates PKCα (light purple) and regulates actin (green) organization and cellular motility, these data indicate that Mdm20 modulates actin remodeling and cellular motility through the mTORC2 pathway. Additionally, Mdm20 regulates not only pAkt (pink), but also pFoxO1 (dark purple), through its effects on mTORC2 activity in response to serum starvation and insulin stimulation. Our findings show that Mdm20 acts as novel regulator of mTORC2 via its ability to regulate Rictor expression and is independent of NatB.