Table 5. Odds ratio for disease outcome in ACS patients with different IL-10 levels or ABO alleles.
Marker | Myocardial infarction after 5 years | Cardiovascular death after 5 years | Any cause of death after 9 years | Any cause of death or myocardial infarction after 5 years | ||||
---|---|---|---|---|---|---|---|---|
OR a [95% CI b ] | P | OR [95% CI] | P | OR [95% CI] | P | OR [95% CI] | P | |
IL-10 (1 SD c increase) | 1.16 [1.04–1.29] | 0.0081 | 1.13 [0.97–1.32] | 0.13 | 1.26 [1.13–1.39] | 1.4 × 10−05 | 1.23 [1.11–1.35] | 4.9 × 10−05 |
rs676457 d (major allele) | 1.26 [1.08–1.47] | 0.0028 | 1.28 [1.02–1.59] | 0.029 | 1.29 [1.11–1.5] | 0.00067 | 1.24 [1.08–1.42] | 0.0025 |
The table shows the odds ratio that is associated with a 1 standard deviation increase in IL-10 levels and the odds ration that is associated with having one extra copy of the major allele of rs676457. The odds ratios, the 95% confidence intervals, and corresponding P-values was estimated for three different endpoints after five our nine years in the ACS cohort.
a OR–odds ratio.
b CI–confidence interval.
c SD–standard deviation.
d The major allele in rs676457 tags the O antigen and is associated with increased IL-10 levels.