Table 3.

Results from Analyses of Pain Growth Factors Predicting 12-Month Drinking Outcomes Mediated by Negative Affect in COMBINE

COMBINE	B (SE; 95% CI)	R2
12-month Percent Drinking Days (PDD) (RMSEA=0.05 (90% CI: 0.04, 0.06), CFI = 0.98)		.28
Baseline PDD	0.48 (0.04)**
Pain interference intercept	0.02 (0.03)
Pain interference slope	−0.71 (0.77)
Negative affect intercept	0.10 (0.02)**
Negative affect slope	2.89 (1.50)
Pain intercept → Affect intercept → PDD Mediation	.01 (.003; 95% CI: .01, .02)**
Pain slope → Affect slope → PDD Mediation	.97 (.71; 95% CI: 0.33, 3.23)*
12-month Drinks/Drinking Day (DDD) (RMSEA=0.05 (90% CI: 0.04, 0.06), CFI = 0.98)		.23
Baseline DDD	0.14 (0.04)**
Pain interference intercept	0.004 (0.004)
Pain interference slope	−0.07 (0.12)
Negative affect intercept	0.02 (0.003)**
Negative affect slope	0.40 (0.22)
Pain intercept → Affect intercept → DDD Mediation	.003 (.001; 95% CI: .002, .004)**
Pain slope → Affect slope → DDD Mediation	.13 (.10; 95% CI: .04, .45)*
12-month % Heavy Drinking Days (PHDD) (RMSEA=0.05 (90% CI: 0.04, 0.06), CFI=.98)		.28
Baseline PHDD	0.33 (0.04)**
Pain interference intercept	0.02 (0.03)
Pain interference slope	−0.69 (0.79)
Negative affect intercept	0.11 (0.02)**
Negative affect slope	3.19 (1.56)*
Pain intercept → Affect intercept → PHDD Mediation	.02 (.003; 95% CI: .01, .02)**
Pain slope → Affect slope → PHDD Mediation	1.07 (.76; 95% CI: .41, 3.43)*
12-month Maximum Drinks/ Day (MXD) (RMSEA=0.05 (90% CI: 0.04, 0.06), CFI=.98)		.23
Baseline MXD	0.07 (0.04)**
Pain interference intercept	0.007 (0.01)
Pain interference slope	−0.11 (0.16)
Negative affect intercept	0.02 (0.004)**
Negative affect slope	0.59 (0.28)*
Pain intercept → Affect intercept → MXD Mediation	.003 (.001; 95% CI: .002, .01)**
Pain slope → Affect slope → MXD Mediation	0.20 (.14; 95% CI: 0.07, 0.64)*

^*p < 0.05;

^**p < 0.01;

B = unstandardized regression coefficient (SE = Standard Error); 95% CI = 95% confidence interval of mediated effect.