. Author manuscript; available in PMC: 2017 Feb 1.

Published in final edited form as: Transl Res. 2015 May 7;168:22–39. doi: 10.1016/j.trsl.2015.04.016

Table 2.

Asthma susceptibility polymorphisms discovered through endophenotypes. The entries of the table have been ordered based on the dates in which the studies were published from the bottom to the top.

Study	Endophenotype	Ancestry				Control + Case (Replicates included)	Genes	Variants	Reference
Study	Endophenotype	European	AFAM	Hispanic	Asian	Control + Case (Replicates included)	Genes	Variants	Reference
Genome-wide association study of lung function decline in adults with and without asthma.	Lung function decline	✓				16136	DLEU7	rs9316500	23
A large-scale, consortium-based genomewide association study of asthma.	IgE levels	✓				30478	IL18R1, HLA-DQ, IL33, SMAD3, GSDMB, GSDMA, IL2RB, HLA-DRB1, FCER1A, IL13, STAT6, IL4-R/IL21R	rs3771166, rs9273349, rs1342326, rs744910, rs2305480, rs3894194, rs2284033, rs9271300, rs2252226, rs20541, rs167769, rs1859308	10
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.	Eosinophil counts	✓			✓	26722	IL1RL1, IKZF2, GATA2, IL5, SH2B3	rs1420101, rs12619285, rs4143832, rs9494145, rs3184504	21
Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.	YKL-40 levels	✓				1772	CHI3L1	rs4950928	22