Table 3.
Patient characteristics during ICU stay
| Continuous control of P cuff | |||
|---|---|---|---|
| Yes (n = 263) | No (n = 280) | p value | |
| SOFA score at randomization | 4 (1, 7) | 4 (2, 6) | 0.538 |
| Subglottic secretion drainage | 53 (20) | 65 (23) | 0.447 |
| Antimicrobial treatment | 237 (90) | 260 (93) | 0.321 |
| MV duration before randomization | 0 (0, 1) | 0 (0, 1) | 0.531 |
| Sucralfate | 42 (16) | 45 (16) | >0.999 |
| Proton-pump inhibitor | 182 (69) | 180 (64) | 0.732 |
| H2 receptor antagonists | 31 (12) | 47 (17) | 0.124 |
| Reintubation | 41 (15) | 30 (11) | 0.120 |
| Mean P cuff | 25 (24, 26) | 22 (21, 24) | <0.001 |
| Underinflation of P cuff | 2 (1) | 118 (42) | <0.001 |
| % P cuff measurements <20 cmH2O | 0 (0,0) | 16 (0, 18) | <0.001 |
| Overinflation of P cuff | 8 (3) | 82 (29) | <0.001 |
| Mean PEEP (cmH2O) | 5 (5, 5) | 5 (5, 5) | 0.358 |
| Sedation | 235 (89) | 253 (90) | 0.806 |
| Ramsay score | 4 (3, 4) | 4 (3, 4) | 0.432 |
| HOB elevation (°) | 37 (30, 40) | 35 (30, 40) | 0.508 |
| Paralytic agent use | 22 (8) | 32 (11) | 0.315 |
| Red blood cell transfusion | 77 (29) | 73 (26) | 0.359 |
| Enteral nutrition | 178 (68) | 195 (70) | 0.689 |
| Tracheostomy | 49 (19) | 41 (15) | 0.257 |
Data are number (%), or median (IQR)
SOFA sequential organ failure assessment, MV mechanical ventilation, P cuff cuff pressure, PEEP positive end expiratory pressure, HOB head of bed