Table 2.
Serum parameters and lipid profile.
| Sham | OVX | Curcumin (mg/Kg/day) | ||
|---|---|---|---|---|
| OVX 50 | OVX 100 | |||
| IL-6 (pg/mL) | 74.73 ± 1.08 | 78.80 ± 0.65c | 75.96 ± 0.56∗ | 75.39 ± 0.72∗ |
| AST activity (U/dL) | 18.937 ± 1.72 | 26.888 ± 1.37c | 25.507 ± 1.22b | 26.975 ± 0.98c |
| ALT activity (U/dL) | 16.974 ± 0.67 | 16.753 ± 0.68 | 16.739 ± 0.48 | 16.979 ± 0.91 |
| HDL (mg/dL) | 30.714 ± 1.99 | 31.666 ± 1.55 | 31.285 ± 1.12 | 29.857 ± 1.47 |
| LDL (mg/dL) | 17.285 ± 2.74 | 26.933 ± 3.40b | 26.171 ± 1.36 | 23.742 ± 1.46 |
| VLDL (mg/dL) | 9.428 ± 1.19 | 8.222 ± 0.75 | 5.714 ± 0.42b | 6.285 ± 0.86b |
| Total cholesterol (mg/dL) | 54.750 ± 3.56 | 70.888 ± 4.41b | 63.857 ± 2.67 | 59.714 ± 3.04 |
| Total triglycerides (mg/dL) | 47.142 ± 5.88 | 40.888 ± 2.27 | 27.714 ± 2.07d | 30.571 ± 4.41d |
IL-6 levels, AST/ALT activities, and lipid profile were measured in serum samples. Sham and OVX groups were treated once a day for 30 days with refined olive oil containing or not curcumin. Data are expressed as mean ± SEM (sham n = 8, OVX n = 11, OVX50 n = 8, OVX100 n = 8).
Statistically different from Sham group: b P < 0.05, c P < 0.01 d P < 0.001; ∗ P < 0.05: different from OVX group (one-way ANOVA followed by Tukey's test).
ALT: alanine aminotransferase; AST: aspartate aminotransferase; HDL: high-density lipoprotein; IL-6: interleukin-6; LDL: low-density lipoprotein; OVX: ovariectomized; VLDL: very low-density lipoprotein.