Table 1.
Recipient and Donor Characteristics (N = 114)
| Characteristic | Result |
|
|---|---|---|
| No. (%) | Median (range) | |
| Recipient age, years | 65 (60-74) | |
| Recipient sex | ||
| Female | 43 (38) | |
| Male | 71 (62) | |
| Cytogenetic risk at diagnosis | ||
| Favorable | 1 (1) | |
| Intermediate | 80 (70) | |
| Adverse | 32 (28) | |
| Complex (including 17p del)* | 26 | |
| del 7 only† | 2 | |
| 11q23 (not t(9;11)) | 2 | |
| Other | 2 | |
| Unknown | 1 (1) | |
| WBC at diagnosis, × 103/mL | 3.9 (0.4-333) | |
| Antecedent hematologic disorder | 20 (18) | |
| One induction course | 70 (61) | |
| No. of consolidation courses | ||
| None | 29 (25) | |
| One | 60 (53) | |
| Two | 24 (21) | |
| Unknown | 1 (1) | |
| Type of consolidation | ||
| High-dose cytarabine based | 48 (56) | |
| Standard-dose cytarabine based or other | 37 (44) | |
| Time from diagnosis to transplantation, days | 138 (61-265) | |
| Time from CR1 documentation to transplantation, days | 85 (9-184) | |
| Donor type | ||
| MRD | 55 (48) | |
| MUD | 59 (52) | |
| Donor age, years | ||
| MRD | 63 (43-81) | |
| MUD | 31 (19-55) | |
| Recipient/donor sex match | ||
| Male/female | 30 (26) | |
| Male/male | 41 (36) | |
| Female/female | 18 (16) | |
| Female/male | 25 (22) | |
| Recipient/donor CMV | ||
| Positive/positive | 33 (29) | |
| Positive/negative | 29 (25) | |
| Negative/positive | 17 (15) | |
| Negative/negative | 30 (26) | |
| Unknown | 5 (4) | |
| ABO compatibility | ||
| Match | 66 (58) | |
| Minor mismatch | 22 (19) | |
| Major mismatch | 24 (21) | |
| Unknown | 2 (2) | |
| Allograft composition | ||
| CD34+ dose/kg (× 106) | 6.2 (0.8-30.5) | |
| CD3+ dose/kg (× 108) | 1.9 (0-5.1) | |
Abbreviations: CMV, cytomegalovirus; CR1, first complete response; MRD, matched related donor; MUD, matched unrelated donor.
*
Complex, three or more cytogenetic abnormalities.
†
17p del, deletion of the short arm of chromosome 17.