Table 3.

Univariable Analysis of Clinical Variables and Their Influence on Outcomes After Transplantation

Covariate	Outcome
	aGVHD Grade 2 to 4		cGVHD		Relapse		NRM		DFS		OS
	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Patient age, years	0.99 (0.84 to 1.16)	.89	1.08 (0.99 to 1.18)	.08	0.99 (0.92 to 1.06)	.71	1.05 (0.94 to 1.18)	.38	1.00 (0.95 to 1.06)	.92	1.0 (0.94 to 1.06)	.94
Male sex	1.54 (0.41 to 5.80)	.52	0.93 (0.45 to 1.90)	.84	0.90 (0.53 to 1.52)	.68	1.56 (0.56 to 4.38)	.39	1.01 (0.64 to 1.62)	.95	0.88 (0.55 to 1.42)	.61
Sex match (yes)	1.63 (0.48 to 5.58)	.43	1.33 (0.65 to 2.69)	.43	0.81 (0.48 to 1.35)	.41	0.82 (0.33 to 2.08)	.68	0.81 (0.51 to 1.27)	.36	0.89 (0.56 to 1.42)	.62
Donor type (MUD)	2.52 (0.67 to 9.50)	.16	0.79 (0.39 to 1.57)	.49	0.97 (0.58 to 1.65)	.92	1.55 (0.60 to 3.99)	.36	1.09 (0.69 to 1.72)	.72	1.06 (0.66 to 1.70)	.80
ATG (yes)	7.4 × 107 (0.00 to inf)	.35	0.26 (0.11 to 0.64)	.002	2.64 (0.63 to 11.08)	.17	0.29 (0.10 to 0.88)	.02	1.04 (0.45 to 2.43)	.93	0.83 (0.35 to 1.95)	.67
Consolidation (yes)	1.62 (0.35 to 7.49)	.53	1.06 (0.47 to 2.35)	.89	0.79 (0.45 to 1.40)	.42	2.57 (0.59 to 11.20)	.19	0.98 (0.58 to 1.66)	.95	1.06 (0.62 to 1.82)	.82
WBC at diagnosis, × 103/mL	1.00 (0.99 to 1.01)	.95	0.98 (0.96 to 1.01)	.12	1.00 (1.00 to 1.01)	.32	0.99 (0.97 to 1.01)	.34	1.00 (1.00 to 1.01)	.66	1.00 (0.99 to 1.00)	.95
Adverse cytogenetic risk	0.64 (0.14 to 3.03)	.57	0.68 (0.28 to 1.66)	.40	1.51 (0.87 to 2.63)	.14	1.51 (0.57 to 4.03)	.40	1.51 (0.93 to 2.45)	.09	1.26 (0.76 to 2.09)	.37
Time from diagnosis to transplantation, days	1.00 (0.99 to 1.02)	.75	1.00 (0.99 to 1.01)	.55	1.00 (0.99 to 1.00)	.17	1.00 (0.99 to 1.01)	.81	1.00 (0.99 to 1.00)	.18	1.00 (0.99 to 1.00)	.10
Time from CR1 to transplantation, days	1.01 (0.99 to 1.02)	.49	0.99 (0.98 to 1.00)	.10	0.99 (0.99 to 1.00)	.08	1.00 (0.99 to 1.01)	.50	1.00 (0.99 to 1.00)	.25	1.00 (0.99 to 1.00)	.22
ABO mismatch (relative to match)
Minor	2.21 (0.50 to 9.89)	.48	2.27 (0.99 to 5.17)	.14	0.68 (0.34 to 1.38)	.24	1.33 (0.44 to 3.97)	.61	0.81 (0.45 to 1.46)	.24	0.86 (0.47 to 1.56)	.18
Major	2.09 (0.47 to 9.32)	.48	1.45 (0.62 to 3.40)	.14	0.58 (0.29 to 1.18)	.4	0.65 (0.17 to 2.39)	.61	0.60 (0.32 to 1.10)	.24	0.55 (0.29 to 1.04)	.18
CD34 (dose/kg × 106)	1.06 (0.96 to 1.17)	.22	0.90 (0.80 to 1.01)	.08	0.93 (0.86 to 1.01)	.10	0.94 (0.82 to 1.08)	.40	0.93 (0.87 to 1.00)	.07	0.96 (0.90 to 1.03)	.23
CD3 (dose/kg × 108)	1.29 (0.73 to 2.25)	.38	0.78 (0.56 to 1.09)	.15	1.32 (1.04 to 1.68)	.02	0.90 (0.57 to 1.43)	.66	1.21 (0.98 to 1.49)	.07	1.23 (1.00 to 1.52)	.05

Abbreviations: aGVHD, acute graft-versus-host disease; ATG, antithymocyte globulin; cGVHD, chronic graft-versus-host disease; CR1, first complete remission; DFS, disease-free survival; HR, hazard ratio; inf, infinity; MUD, matched unrelated donor; NRM, nonrelapse mortality; OS, overall survival.