TABLE 2.
Noncompartmental, single-dose kinetics after oral ingestion of 13C-lycopene in 8 healthy adults1
| Analyte and parameter | Total | All-trans | Total cis isomers | 5-cis |
| 13C-Lycopene | ||||
| Cmax, μM | 0.14 ± 0.022 | 0.10 ± 0.02 | 0.04 ± 0.01 | 0.03 ± 0.004 |
| Tmax, h | 30 ± 6 | 28 ± 7 | 48 ± 9 | 42 ± 9 |
| AUC (0–672), μmol · h−1 · L−1 | 31 ± 3 | 17 ± 3 | 11 ± 2 | 7 ± 1 |
| Total AUC, % | – | 55 | 35 | 23 |
| t1/2, d | 6.2 ± 0.3 | 5.3 ± 0.3 | 8.8 ± 0.6 | 9.8 ± 0.8 |
| Native lycopene | ||||
| Baseline (day 0) plasma concentration, μmol/L | 0.60 ± 0.10 | 0.23 ± 0.05 | 0.33 ± 0.08 | 0.20 ± 0.04 |
| Final (day 28) plasma concentration, μmol/L | 0.86 ± 0.06 | 0.35 ± 0.03 | 0.45 ± 0.07 | 0.27 ± 0.04 |
1
Cmax, time to reach maximal plasma 13C-lycopene concentration; Tmax, time to reach maximal plasma concentration; t1/2, half-life.
2
Mean ± SEM (all such values).