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. 2015 Nov 25;5:16788. doi: 10.1038/srep16788

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Copyright © 2015, Macmillan Publishers Limited

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(a) Schematic of nanotrain formation: aptamer PL8t is represented in purple. The trigger is in green and the monomers M1 and M2 are respectively in orange and blue. (b) PL8, PL8t and NT8 show similar binding affinity towards PL45 cells. (c) PL8 and PL8t show no affinity for hTERT HPNE; however NT8 shows some affinity for these cells. (d) PL45 (target) and HPNE (control) cells were incubated for 2 h with the doxorubicin loaded nanotrain (NT8:Dox) and cultured thereafter for 48 h. A dose dependent response was achieved for the target cells, while the control cells showed a constant viability (above 75%). The viability at 0 μM represents the viability of cells incubated with only NT8.