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Inhibition of hOCT1, hOCT2, hMATE1, and hMATE2-K by R- and S-atenolol. Uptake of 1 μM ASP+ in the absence and presence of R- and S-atenolol was measured in both transporter-expressing and control HEK cells. The uptake of ASP+ in the presence of R- and S-atenolol was expressed as a percentage of the uptake in the absence of R- and S-atenolol. Five minutes was chosen as the end point for specific uptake. Each data point represents the mean ± S.D.
