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. 2015 Nov 25;5:17066. doi: 10.1038/srep17066

Figure 5. Methoxyamine potentiates ß-lap-induced PARP1-dependent metabolic catastrophe.

Figure 5

(A) Relative ATP recovery in MiaPaca2 cells after a 2 h treatment with or without ß-lap, ±12 mM MeOX assessed over a 4 h time period by CellTiter-Glo assays. (B,C) Time-course of lactate production and glucose consumption over a 6 h period in media of MiaPaca2 cells after a 2 h treatment with ß-lap, ±12 mM MeOX. (D) Glucose consumption assessments from media of MiaPaca2 cells treated with Rucaparib (25 μM) for 2 h and then exposed to ß-lap ±12 mM MeOX for 2 h. Data represent means ±SEM from triplicate samples. All results were compared using Student’s t-tests (+/− standard deviation) unless otherwise stated. *p < 0.05; **p < 0.01; ***p < 0.001.